The new system developed by Professor Chad Mirkin delivers CRISPR machinery more safely and effectively into cells.

DNA end resection is crucial for most DNA double-strand break repair pathways. This Review discusses the molecular mechanisms of end resection and its regulation, focusing on the roles of post ...

To repair double-strand breaks in DNA, homologous DNA sequences must find each other. According to Minsky and colleagues, random diffusion of DNA molecules is too slow for timely repair of these ...

Scientists study a molecular machine that moves jumping genes in DNA, paving the way for a new gene editing tool beyond ...

Using optical tweezers, researchers observed individual binding events in real time, offering new insights into the molecular ...

In a happy accident, researchers in UCSB biologist Chris Richardson's lab find a way to improve nonviral gene editing as well as a new mechanism for DNA repair ...

The DNA damage repair (DDR) pathway is frequently altered in cancer, and cellular responses to DNA damage constitute one of the most important fields in cancer biology. The success of PARP inhibitor ...

New regulatory cues facilitate cellular decisions of the DNA repair mechanism to be adopted in the event of double strand damage.

Preserving its DNA ought to be a cell’s top priority. But bacteria slow their DNA repair to a crawl in favor of proofreading gene transcripts.

Combining an optical tweezer technology called C-trap that manipulates a single molecule of DNA and a novel approach, researchers were able to receive a detailed view into how cells find and ...

Scientists at the Francis Crick Institute, in collaboration with Artios, have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the ...

Scientists discovered that a well-known DNA repair pathway, the Fanconi anemia pathway, surprisingly plays a key role in repairing double-strand DNA breaks created by CRISPR-Cas9. It acts as a ...