本研究提出了一种基于错配 crRNA 的 CRISPR/Cas12a 检测平台，实现了对 kelch13 基因 Q613、Q613E 和 Q613H ...

CRISPR screening is a cost‑effective, and potentially cost-saving, approach, because it derisks drug development. However, developing a screening platform and recruiting people with the ...

A CRISPR system detects rare cancer mutations in blood with single-nucleotide precision, outperforming ddPCR through ...

CRISPR libraries offer huge advantages for high-throughput screening, including unprecedented editing efficiency, accuracy, and speed. This article walks through the fundamentals of CRISPR screening ...

How CRISPR Is Revolutionizing Screening Technology CRISPR facilitates the creation of knockout, interference, and activation screens that precisely and comprehensively interrogate genomic function ...

Yicheng Wang, Anant K. Menon, Yuta Maki, Yi-Shi Liu, Yugo Iwasaki, Morihisa Fujita, Paula A. Guerrero, Daniel Varó’n Silva, Peter H. Seeberger, Yoshiko Murakami, Taroh Kinoshita, Genome-wide CRISPR ...

For trouble-free CRISPR screening workflows, choose the right modality, format, and gRNA library strategy.

Using a genomewide CRISPR knockout screen, we identified placenta-associated 8 protein (PLAC8) as an essential host factor for SADS-CoV infection. Knockout of PLAC8 abolished SADS-CoV infection, which ...

A CRISPR screening tool identified a new therapeutic target to treat acute myeloid leukemia (AML) that has the potential to leave patients with fewer side effects than current approaches ...

CRISPR screen identifies new anti-inflammatory drug target Date: November 11, 2021 Source: Vanderbilt University Medical Center Summary: A metabolic enzyme that has been studied in cancer biology ...